Global point of care
Sepsis:
Transform Risk Stratification at the bedside
Sepsis: Transform Risk Stratification at the bedside
A deadly and costly crisis
Common
~1 in 3 patients who die in the hospital have sepsis1
Costly
#1 inpatient cost in US hospitals, totaling >$27 billion/year2
Consequential
Leading cause of US in-hospital mortality, up to 70% in patients with septic shock3,4
sepsis mortality — one hour makes all the difference
An updated, evidence-based bundle from the Surviving Sepsis Campaign (SSC), released in 2018, emphasizes expediency of care to improve survival.
2018 SSC Hour-1 Bundle |
| Measure lactate level. Re-measure if initial lactate is >2 mmol/L |
| Obtain blood cultures prior to administration of antibiotics |
| Administer broad-spectrum antibiotics |
| Rapidly administer 30 ml/kg crystalloid for hypotension or lactate ≥4 mmol/L |
| Apply vasopressors if patient is hypotensive during or after fluid resuscitation to maintain MAP ≥65 mm Hg |
- Lactate-guided resuscitation is associated with significantly reduced mortality5
- Yet only 53% of clinicians order lactate with blood culture for patients with sepsis4
- When lactate is ordered, long turnaround times have been identified as a barrier to bundlecompliance4
8%
Every hour
sepsis treatment
is delayed once
the patient has
developed
hypotension,
risk of death
increases by up
to 8%9
Sepsis mortality — one hour makes all the difference
An updated, evidence-based bundle from the Surviving Sepsis Campaign (SSC), released in 2018, emphasizes expediency of care to improve survival.
2018 SSC Hour-1 Bundle |
| Measure lactate level. Re-measure if initial lactate is >2 mmol/L |
| Obtain blood cultures prior to administration of antibiotics |
| Administer broad-spectrum antibiotics |
| Rapidly administer 30 ml/kg crystalloid for hypotension or lactate ≥4 mmol/L |
| Apply vasopressors if patient is hypotensive during or after fluid resuscitation to maintain MAP ≥65 mm Hg |
- Lactate-guided resuscitation is associated with significantly reduced mortality5
- Yet only 53% of clinicians order lactate with blood culture for patients with sepsis4
- When lactate is ordered, long turnaround times have been identified as a barrier to bundlecompliance4
8%
Every hour sepsis treatment is
delayed once the patient has
developed hypotension, risk of
death increases by up to 8%9
Sepsis mortality — one hour makes all the difference
An updated, evidence-based bundle from the Surviving Sepsis Campaign (SSC), released in 2018, emphasizes expediency of care to improve survival.
2018 SSC Hour-1 Bundle |
| Measure lactate level. Re-measure if initial lactate is >2 mmol/L |
| Obtain blood cultures prior to administration of antibiotics |
| Administer broad-spectrum antibiotics |
| Rapidly administer 30 ml/kg crystalloid for hypotension or lactate ≥4 mmol/L |
| Apply vasopressors if patient is hypotensive during or after fluid resuscitation to maintain MAP ≥65 mm Hg |
- Lactate-guided resuscitation is associated with significantly reduced mortality5
- Yet only 53% of clinicians order lactate with blood culture for patients with sepsis4
- When lactate is ordered, long turnaround times have been identified as a barrier to bundlecompliance4
8%
Every hour sepsis
treatment is delayed
once the patient has
developed
hypotension, risk of
death increases by up
to 8%9
Solutions
i-STAT CG4+ — Expediting Risk Stratification to optimize acuity-based care
When every minute counts, i-STAT CG4+ improves care team efficiency, coordination, and communication – quickly guiding resources to those who need it most.
In clinical studies, i-STAT CG4+ has been shown to significantly improve ED efficiency and quality
- Reduced door-to-lactate result time by 72%6
- Reduced ED care time (arrival-to-disposition decision) by 11%7
- Provided a cost-effective means to identify patients benefitting from early resuscitation8
Related Items
Testing for Lactate with CG4+
i-STAT 1 Analyzer
In clinical studies, i-STAT CG4+ has been shown to significantly improve ED efficiency and quality
- Reduced door-to-lactate result time by 72%6
- Reduced ED care time (arrival-to-disposition decision) by 11%7
- Provided a cost-effective means to identify patients benefitting from early resuscitation8
Related Items
Testing for Lactate with CG4+
i-STAT 1 Analyzer
Want more information about how your organization can achieve sepsis care transformation?
References
1. CDC Sepsis Fact Sheet.
2. What is Sepsis? Infographic. Sepsis Alliance. www.sepsis.org
3. Sepsis Alliance Sepsis Fact Sheet.
4. Advisory Board Sepsis Research Report.
5. Levy MM, Evans LE, Rhodes A.
6. Singer AJ, Taylor M, LeBlanc D et al. 2014.
7. Singer AJ, Taylor M, LeBlanc D et al. 2018.
8. Ward MJ, Self WH, Singer A et al.
9. Kumar et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. June 2006. https://www.ncbi.nlm.nih.gov/pubmed/16625125
