Summary

Dengue is one of the most highly emerging mosquito-transmitted flavivirus infections, with an increasing number of cases in recent years. Rapid global spread of dengue is associated with higher population density, climate change, an increase in frequency of air travel, among other factors. According to estimations from Brazil’s Ministry of Health, approximately 6 million cases of dengue were suspected in the first half of 2024. Nearly 56,000 cases were registered in the first 15 days of 2024 compared to 26,801 cases during the same period in 2023, representing an increase of 108%. As reported in a recent publication, the Resurgence of Dengue Virus Serotype 2, Bangladesh experienced the largest and most deadly dengue outbreak in 2023 since the reemergence of virus two decades ago. In Sri Lanka, scientific evidence showed two co-circulating genotypes of dengue virus serotype 3 (I and III) were responsible for large dengue outbreaks in the country with genotype I not being detected by certain PCR primers. 

Watch this global webinar for insights from regional experts on this growing and challenging epidemic in endemic areas.

Learning Objectives

• Examine dengue epidemiology and in-country impact with re-introduction of dengue serotypes.
• Describe societal, logistical, and technical challenges associated with the diagnosis of dengue.
• Summarize evidence and strategies to detect and control infection.
• Discuss the impact of genotypic variation on dengue diagnosis.

Dr. Mauricio Nogueira, Associate Professor
Laboratório de Pesquisas em Virologia
Faculdade de Medicina de São José do Rio Preto
SP Brazil

Mauricio Nogueira is a Professor of Microbiology and Infectious Diseases at Faculdade de Medicina de SJ Rio Preto (FAMERP) in Brazil. He received a MD and a PhD from Federal University of Minas Gerais and then completed a postdoctoral training at NIAID, Bethesda. He is currently Chair of ACAV/ASTMH and is an associate adjunct professor at Department of Pathology, University of Texas Medical Branch.

“Dengue and Chikungunya Outbreaks in Brazil (2024)”

Dr. Mohammad Shafiul Alam, Scientist, Enteric and Respiratory Infections
Infectious Diseases Division
icddr,b Bangladesh

Mohammad Shafiul Alam, a Scientist with a PhD in Parasitology, leads the Parasitic and Vector-borne Infections Unit of the Infectious Diseases Division at icddr,b. He has received advanced training in point-of-care diagnostics from leading institutions, including the University of Tokyo, Fondation Mérieux, PATH, and the University of Washington. Recently, he has been involved in NIH-sponsored dengue vaccine trials in Bangladesh. Additionally, Dr. Alam is conducting multiple studies on the epidemiology and diagnostic evaluation of arbovirus transmission in Bangladesh.

“The 2023 Dengue Surge in Bangladesh: Impact of Dengue Serotype 2 Resurgence”

Dr. Gathsaurie Neelika Malavige, Professor, Department of Immunology and Molecular Medicine
University of Sri Jayewardenepura
Sri Lanka

Neelika Malavige is a Professor at the Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura, Sri Lanka and an academic visitor at the Weatherall Institute of Molecular Medicine, University of Oxford. She is a member of the Executive Committee of the International Society of Infectious Diseases and a member of many national committees and technical advisory committees on dengue control, communicable diseases, and vaccines in Sri Lanka. Her research focus has been on immunopathogenesis of dengue, biomarkers and immune correlates of protection and translating these findings into clinical trials.

“Evolution of the Dengue Virus: Why it Matters for Diagnostics”